Bacterial infections represent a major challenge in aquaculture, leading to significant economic losses, reduced productivity, and increased mortality in fish and shellfish. The widespread use of antibiotics has contributed to antimicrobial resistance, environmental contamination, and increasing regulatory pressure, highlighting the need for sustainable and effective alternatives. Phage biocontrol has emerged as a promising solution; however, its transition from experimental validation to standardized industrial application remains limited by challenges related to robustness, scalability, and integration into existing aquaculture workflows.

In this communication will be discussed the application of phages targeting major aquaculture pathogens, including Escherichia coli, Salmonella, Aeromonas spp., and Vibrio spp., both as single suspensions and cocktails, under conditions simulating aquaculture settings (fish culture tanks, bivalve depuration systems, and live feeds culture tanks), in order to support the broader adoption of phage biocontrol in industrial aquaculture and contribute to global efforts to reduce antibiotic dependence and promote sustainability.