Nearly complete structure of bacteriophage DT57C has been revealed

Architecture of the DT57C bacteriophage. Scientists have unraveled the intricate molecular structure of bacteriophage DT57C, a member of the T5 family of tailed bacteriophages. These viruses are characterized by a long non-contractile tail and play a vital role in controlling bacterial populations. The DT57C bacteriophage, closely related to the well-known T5 phage, exhibits unique characteristics,…

Enhancing Precision in Phage Therapy: Insights from Phage Annotation and Nomenclature

A paper  by Robert A Edwards and Bhavya Papudeshi from Flinders University, focused on refining the understanding and application of bacteriophages. Bacteriophages are viruses that infect bacteria, exerting a significant influence on microbial communities and ecosystems. They have garnered considerable attention for their potential role in combating antibiotic resistance. Phage therapy predominantly relies on lytic…

Exploring Phage Therapy: From Biological Mechanisms to Future Directions

Potential phage therapy applications from the One Health perspective In response to escalating antimicrobial resistance rates, the field of bacteriophage (phage) therapy, led by Robert T. Schooley and his team at the Center for Innovative Phage Applications and Therapeutics, Division of Infectious Disease and Global Public Health, University of California, San Diego, La Jolla, CA,…

Phage Therapy Targets Gut Microbiota for Liver Disease Treatment

In a significant development, phage therapy is emerging as a solution against antimicrobial-resistant bacteria, marking a shift from conventional antibiotic treatments. Recognizing the intricate connection between bacterial microbiota and gastrointestinal/liver diseases, researchers are aiming to leverage phages’ precise bactericidal action for targeted editing of the gut microbiota. Fujiki et al. provided an overview of the…
Virus Attacks Dormant Bacteria, Offering New Hope in Antibiotic Resistance Fight

Virus Attacks Dormant Bacteria, Offering New Hope in Antibiotic Resistance Fight

After six years of research, teams from the University of Basel and ETH Zurich have discovered a potentially crucial weapon against antibiotic-resistant bacteria: a virus named Paride that preys on and kills dormant bacteria. This bacterium, Pseudomonas aeruginosa, which can cause severe respiratory diseases and potentially fatal pneumonia, often enters a dormant state as a…

Bacteriophage Partnerships: Enhancing Stem Cell Transplant Success

Intestinal tissue during a graft-versus-host reaction: Donor cells (red) attack the body of the patient. Credit: Sebastian Jarosch, Dirk Busch / TUM After stem cell transplantation, the donated immune cells sometimes attack the patients’ bodies. This is known as graft versus host disease or GvHD. Researchers at the Technical University of Munich (TUM) and the Universitätsklinikum…

Rapid Bench to Bedside Therapeutic Bacteriophage Production

An excellent paper by Luong et al. from San Diego State University has recently been published by Springer on Bacteriophage Therapy: From Lab to Clinical Practice. The comprehensive content of the paper includes: 1. Historical Context: Bacteriophages have been used in human therapeutics for over a century, with significant advancements in production techniques. 2. Modern…

How Bacteria Spot Viral Invasion and Ramp Up Immune Defenses?

A viral RNA produced during Φ80α-vir infection activates Ssc-CdnE03 in vitro Researchers at The Rockefeller University’s Laboratory of Bacteriology have uncovered a novel mechanism through which bacteria defend against viral infections, known as the cyclic oligonucleotide-based antiphage signaling system (CBASS). This intricate immune response protects prokaryotes by triggering the production of cyclic oligonucleotides, activating proteins…

Phables: Advancing Phage Research for a Healthier Future

Processing workflow. Credits: Flinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University In a significant leap forward for phage research, Flinders University’s College of Science and Engineering introduces “Phables”, a bioinformatics software program designed to address the challenges in identifying and characterizing phage genomes within fragmented viral metagenome assemblies. This innovative tool,…

New Structural Antibiotic Classes Discovered through Explainable Deep Learning

In the relentless pursuit of novel solutions to combat the escalating antibiotic resistance crisis, a groundbreaking paper, published in the Nature Journal, reveals a pioneering approach to the discovery of new structural classes of antibiotics. The paper challenges the current status quo in antibiotic discovery by leveraging the power of deep learning. Acknowledging the urgency…