Ms. Alena Kaltenbrunner, University of Bologna, Italy will join the 8th World Congress Targeting Therapy in Berlin.
Topic :
Engineering Phages for Cancer Therapy: Insights into Immune Interactions and Targeting in Ex-Vivo and In-Vivo Models.
Summary :
Filamentous bacteriophages are emerging as innovative tools for cancer therapy, offering precise targeting of malignant cells and delivering drugs specifically. In this talk, I will present recent progress in engineering M13 phages for targeted photodynamic cancer therapy (PDT). I will provide new insights into macrophage-phage interactions and immune activation, addressing key challenges such as immune clearance and modulation of the tumour microenvironment. I will also present new results of this phage-based therapy applied in ex vivo patient-derived ascites and in vivo tumour-bearing mice as well as in zebrafish models. This research paves the way for optimising phage applications in oncology and improving their clinical translation.
Targeting Phage Therapy 2025
June 10-11, 2025 – Berlin, Germany