Category: Latest News

Call for Participation – Phage Therapy Task Force – EU Horizon Europe 2025

Call for Participation – Phage Therapy Task Force – EU Horizon Europe 2025

Posted on by Targeting Phage Therapy
Join the European Phage Therapy Consortium In the context of the Horizon Europe 2025 Health Work Programme, a major opportunity is open under the call HORIZON-HLTH-2025-01-DISEASE-01: “Testing safety and efficacy of phage therapy for the treatment of antibiotic-resistant bacterial infections.” We are launching the Phage Therapy Task Force to build a credible, multidisciplinary consortium able…
Posted on June 30, 2025
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Clinical Application of Bacteriophage Therapy in Children

Clinical Application of Bacteriophage Therapy in Children

Posted on by Targeting Phage Therapy
Bacteriophage therapy, which uses viruses that target specific bacterial pathogens, is being considered as a potential alternative to antibiotics, particularly for pediatric patients with multidrug-resistant infections. This approach offers the advantage of targeting only the harmful bacteria, reducing the disruption to the child’s microbiome commonly seen with antibiotics. Bacteriophages can be applied topically or systemically,…
Posted on February 19, 2025
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Bacteriophage Therapy: A New Approach for Severe Bacterial Infections

Bacteriophage Therapy: A New Approach for Severe Bacterial Infections

Posted on by Targeting Phage Therapy
 Bacteria acquire phage resistance. The increasing prevalence of antibiotic-resistant bacteria presents a critical global health challenge. According to the WHO, 1.27 million deaths in 2019 were linked to resistant infections, and by 2050, fatalities from these infections are projected to exceed those caused by cancer. The Role of Phage Therapy As an alternative to antibiotics,…
Posted on February 19, 2025
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KlebPhaCol: Revealing the Gut’s Hidden Phage Potential in Klebsiella Research

KlebPhaCol: Revealing the Gut’s Hidden Phage Potential in Klebsiella Research

Posted on by Targeting Phage Therapy
The human gut is a complex ecosystem where bacteriophages play a crucial but often overlooked role. Now, KlebPhaCol, a community-driven resource developed by Franklin L. Nobrega and colleagues, provides a comprehensive collection of 53 phages and 74 Klebsiella isolates, offering valuable insights into phage-bacteria interactions in the gut. One of the most exciting discoveries is…
Posted on February 11, 2025
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The Hidden Architects of the Gut: Phage-Bacteria Dynamics in Early Childhood Development

The Hidden Architects of the Gut: Phage-Bacteria Dynamics in Early Childhood Development

Posted on by Targeting Phage Therapy
A schematic of factors potentially accounting for high virus (phage) turnover in human guts. This study explores the dynamic relationship between bacteriophages (phages) and bacteria in the gut microbiome of infants and young children during their early years. Using metagenomic sequencing data from over 12,000 stool samples collected as part of the Environmental Determinants of Diabetes in…
Posted on January 27, 2025
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Personalized Bacteriophage Therapy: Insights from 100 Consecutive Cases

Personalized Bacteriophage Therapy: Insights from 100 Consecutive Cases

Posted on by Targeting Phage Therapy
Jean-Paul Pirnay and his team from the Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium, and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Non-traditional Antibacterial Therapy (ESGNTA), Basel, Switzerland, have presented a detailed analysis of personalized bacteriophage therapy (BT) outcomes. This retrospective observational study analyzed…
Posted on December 12, 2024
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Exploring the Phageome: Differences in Healthy and Atopic Dermatitis Skin

Exploring the Phageome: Differences in Healthy and Atopic Dermatitis Skin

Posted on by Targeting Phage Therapy
Study workflow and bacterial communities in healthy skin and AD. In this study published in Science Advances, Wolfgang Weninger and his team from the Medical University of Vienna, have highlighted the role of bacteriophages in the skin’s microbiome, particularly in relation to atopic dermatitis (AD). By analyzing skin swabs from both healthy individuals and AD…
Posted on May 15, 2024
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Untapped Potential: Phage Model Systems as Next-Generation Therapeutic Agents

Untapped Potential: Phage Model Systems as Next-Generation Therapeutic Agents

Posted on by Targeting Phage Therapy
Researchers from the Max Planck Institute for Evolutionary Biology have introduced an innovative approach to strengthen the effectiveness of phage therapy against drug-resistant bacteria. As antibiotic resistance continues to rise globally, finding alternative treatments is increasingly urgent, and phages – viruses that target bacteria – have emerged as a promising option. The proposed procedure to…
Posted on April 5, 2024
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Armed phages are heading for clinical trials

Armed phages are heading for clinical trials

Posted on by Targeting Phage Therapy
Armed phages, engineered to carry a CRISPR–Cas , have demonstrated remarkable efficacy in combating Escherichia coli infections in animal models. Led by Antonia P. Sagona and Jessica Maree Lewis from the School of Life Sciences at the University of Warwick in Coventry, UK, this research represents significant progress in the fight against bacterial infections. By…
Posted on March 22, 2024
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Vibrio cholerae CBASS System Revolutionizes Antibiotic Sensitivity

Vibrio cholerae CBASS System Revolutionizes Antibiotic Sensitivity

Posted on by Targeting Phage Therapy
On-target antifolate activity is essential for CBASS–antifolate interaction in V. cholerae. A recent study led by Ana Rita Brochado, published in Nature Microbiology, shed light on the modulation of resistance and killing by antifolate antibiotics through the Vibrio cholerae CBASS phage defense system. In their research, Brochado and her team, discovered that the cyclic-oligonucleotide-based anti-phage signaling system…
Posted on March 4, 2024
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