Category: Latest News

Bacteriophage therapy, which uses viruses that target specific bacterial pathogens, is being considered as a potential alternative to antibiotics, particularly for pediatric patients with multidrug-resistant infections. This approach offers the advantage of targeting only the harmful bacteria, reducing the disruption to the child’s microbiome commonly seen with antibiotics. Bacteriophages can be applied topically or systemically,…

The human gut is a complex ecosystem where bacteriophages play a crucial but often overlooked role. Now, KlebPhaCol, a community-driven resource developed by Franklin L. Nobrega and colleagues, provides a comprehensive collection of 53 phages and 74 Klebsiella isolates, offering valuable insights into phage-bacteria interactions in the gut. One of the most exciting discoveries is…

Jean-Paul Pirnay and his team from the Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium, and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Non-traditional Antibacterial Therapy (ESGNTA), Basel, Switzerland, have presented a detailed analysis of personalized bacteriophage therapy (BT) outcomes. This retrospective observational study analyzed…

Researchers from the Max Planck Institute for Evolutionary Biology have introduced an innovative approach to strengthen the effectiveness of phage therapy against drug-resistant bacteria. As antibiotic resistance continues to rise globally, finding alternative treatments is increasingly urgent, and phages – viruses that target bacteria – have emerged as a promising option. The proposed procedure to…

On-target antifolate activity is essential for CBASS–antifolate interaction in V. cholerae. A recent study led by Ana Rita Brochado, published in Nature Microbiology, shed light on the modulation of resistance and killing by antifolate antibiotics through the Vibrio cholerae CBASS phage defense system. In their research, Brochado and her team, discovered that the cyclic-oligonucleotide-based anti-phage signaling system…