Category: Latest News

The Hidden Architects of the Gut: Phage-Bacteria Dynamics in Early Childhood Development

The Hidden Architects of the Gut: Phage-Bacteria Dynamics in Early Childhood Development

Posted on by Targeting Phage Therapy
A schematic of factors potentially accounting for high virus (phage) turnover in human guts. This study explores the dynamic relationship between bacteriophages (phages) and bacteria in the gut microbiome of infants and young children during their early years. Using metagenomic sequencing data from over 12,000 stool samples collected as part of the Environmental Determinants of Diabetes in…
Posted on January 27, 2025
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Personalized Bacteriophage Therapy: Insights from 100 Consecutive Cases

Personalized Bacteriophage Therapy: Insights from 100 Consecutive Cases

Posted on by Targeting Phage Therapy
Jean-Paul Pirnay and his team from the Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium, and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Non-traditional Antibacterial Therapy (ESGNTA), Basel, Switzerland, have presented a detailed analysis of personalized bacteriophage therapy (BT) outcomes. This retrospective observational study analyzed…
Posted on December 12, 2024
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Exploring the Phageome: Differences in Healthy and Atopic Dermatitis Skin

Exploring the Phageome: Differences in Healthy and Atopic Dermatitis Skin

Posted on by Targeting Phage Therapy
Study workflow and bacterial communities in healthy skin and AD. In this study published in Science Advances, Wolfgang Weninger and his team from the Medical University of Vienna, have highlighted the role of bacteriophages in the skin’s microbiome, particularly in relation to atopic dermatitis (AD). By analyzing skin swabs from both healthy individuals and AD…
Posted on May 15, 2024
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Untapped Potential: Phage Model Systems as Next-Generation Therapeutic Agents

Untapped Potential: Phage Model Systems as Next-Generation Therapeutic Agents

Posted on by Targeting Phage Therapy
Researchers from the Max Planck Institute for Evolutionary Biology have introduced an innovative approach to strengthen the effectiveness of phage therapy against drug-resistant bacteria. As antibiotic resistance continues to rise globally, finding alternative treatments is increasingly urgent, and phages – viruses that target bacteria – have emerged as a promising option. The proposed procedure to…
Posted on April 5, 2024
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Armed phages are heading for clinical trials

Armed phages are heading for clinical trials

Posted on by Targeting Phage Therapy
Armed phages, engineered to carry a CRISPR–Cas , have demonstrated remarkable efficacy in combating Escherichia coli infections in animal models. Led by Antonia P. Sagona and Jessica Maree Lewis from the School of Life Sciences at the University of Warwick in Coventry, UK, this research represents significant progress in the fight against bacterial infections. By…
Posted on March 22, 2024
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Vibrio cholerae CBASS System Revolutionizes Antibiotic Sensitivity

Vibrio cholerae CBASS System Revolutionizes Antibiotic Sensitivity

Posted on by Targeting Phage Therapy
On-target antifolate activity is essential for CBASS–antifolate interaction in V. cholerae. A recent study led by Ana Rita Brochado, published in Nature Microbiology, shed light on the modulation of resistance and killing by antifolate antibiotics through the Vibrio cholerae CBASS phage defense system. In their research, Brochado and her team, discovered that the cyclic-oligonucleotide-based anti-phage signaling system…
Posted on March 4, 2024
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Nearly complete structure of bacteriophage DT57C has been revealed

Nearly complete structure of bacteriophage DT57C has been revealed

Posted on by Targeting Phage Therapy
Architecture of the DT57C bacteriophage. Scientists have unraveled the intricate molecular structure of bacteriophage DT57C, a member of the T5 family of tailed bacteriophages. These viruses are characterized by a long non-contractile tail and play a vital role in controlling bacterial populations. The DT57C bacteriophage, closely related to the well-known T5 phage, exhibits unique characteristics,…
Posted on February 26, 2024
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Enhancing Precision in Phage Therapy: Insights from Phage Annotation and Nomenclature

Enhancing Precision in Phage Therapy: Insights from Phage Annotation and Nomenclature

Posted on by Targeting Phage Therapy
A paper  by Robert A Edwards and Bhavya Papudeshi from Flinders University, focused on refining the understanding and application of bacteriophages. Bacteriophages are viruses that infect bacteria, exerting a significant influence on microbial communities and ecosystems. They have garnered considerable attention for their potential role in combating antibiotic resistance. Phage therapy predominantly relies on lytic…
Posted on February 21, 2024
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Exploring Phage Therapy: From Biological Mechanisms to Future Directions

Exploring Phage Therapy: From Biological Mechanisms to Future Directions

Posted on by Targeting Phage Therapy
Potential phage therapy applications from the One Health perspective In response to escalating antimicrobial resistance rates, the field of bacteriophage (phage) therapy, led by Robert T. Schooley and his team at the Center for Innovative Phage Applications and Therapeutics, Division of Infectious Disease and Global Public Health, University of California, San Diego, La Jolla, CA,…
Posted on February 15, 2024
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Phage Therapy Targets Gut Microbiota for Liver Disease Treatment

Phage Therapy Targets Gut Microbiota for Liver Disease Treatment

Posted on by Targeting Phage Therapy
In a significant development, phage therapy is emerging as a solution against antimicrobial-resistant bacteria, marking a shift from conventional antibiotic treatments. Recognizing the intricate connection between bacterial microbiota and gastrointestinal/liver diseases, researchers are aiming to leverage phages’ precise bactericidal action for targeted editing of the gut microbiota. Fujiki et al. provided an overview of the…
Posted on February 9, 2024
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