Latest News - 6th World Congress on Targeting Phage Therapy 2023 - June 1-2, 2023 - Paris, France

Gut Bacteriophage Dynamics During Fecal Microbial Transplantation in Metabolic Syndrome Subjects

Posted on July 7, 2022December 13, 2022 by Targeting Phage Therapy

Metabolic Syndrome (MetS) is a growing public health concern worldwide. A healthy gut microbiota is associated with a reduction in MetS. Treatment of MetS with fecal microbiota transplantation (FMT) can be effective, however, its success rate is intermediate and difficult to predict. Because bacteriophages significantly affect the microbiota membership and function, the aim of this…

Engineering T4 Bacteriophage for In-Vivo Display via Type V CRISPR-Cas Genome Editing

Posted on July 7, 2022December 13, 2022 by Targeting Phage Therapy

Bacteriophage T4 has enormous potential for biomedical applications due to its large size, capsid architecture, and high payload capability for protein and DNA delivery. However, it is not very easy to genetically engineer its genome heavily modified by cytosine hydroxymethylation and glucosylation. The glucosyl hydroxymethyl cytosine (ghmC) genome of phage is completely resistant to most…

Luminescence Modulating Phages for Detecting Disease Associated Biomarkers

Posted on July 6, 2022December 13, 2022 by Targeting Phage Therapy

Assessment of risk for a given disease and the diagnosis of diseases is often based on assays detecting biomarkers. Antibody-based biomarker-assays for diseases such as prostate cancer are often ambiguous and biomarker proteins are frequently also elevated for reasons that are unspecific. Kulpakko et al. have opted to use luminescence modulating phages for the analysis…

Phages to shape the gut microbiota?

Posted on March 25, 2022December 13, 2022 by Targeting Phage Therapy

The phage therapy concept is simple; target the phage to the bacterial pathogen causing disease. As phages are natural killers of bacteria, one could expect this to be an easy task. However, when it comes to phage therapy within the gut, it might not be quite that simple. Already without exogenous intervention, a multitude of…

Programmed M13 Bacteriophage Inspired Nose

Posted on February 24, 2022January 23, 2023 by Targeting Phage Therapy

Based on the programable surface chemistry of M13 bacteriophage and inspired by the neural mechanism of the mammalian olfactory system, Lee et al., proposed an electronic nose. The neural pattern separation (NPS) was devised to apply the pattern separation that operates in the memory and learning process of the brain to the electronic nose. This…

Phage Therapy Against SARS-Cov-2

Posted on February 24, 2022August 16, 2022 by Targeting Phage Therapy

Non-tailed phages with multifaceted capsid morphology (Cystoviridae, Leviviridae, Corticoviridae, Tectiviridae) and pleomorphic phages (Plasmaviridae). Knowing that one of the life threatening aspects of COVID-19 is secondary infections and reduced efficacy of antibiotics against them, Shahin et. al, brilliantly discussed the potential applications of bacteriophages in the fight against the present pandemic and the post-COVID era.…

Phage infection mediates inhibition of bystander bacteria

Posted on June 18, 2020February 25, 2022 by Targeting Phage Therapy

Phage infection mediates inhibition of bystander bacteria Bacteriophages (phages) are being considered as alternative therapeutics for the treatment of multidrug resistant bacterial infections. Considering phages have narrow host-ranges, it is generally accepted that therapeutic phages will have a marginal impact on non-target bacteria. We have discovered that lytic phage infection induces transcription of type VIIb…

Scientists hope to fight antibiotic-resistant bacteria by targeting their ‘alarm proteins’

Posted on December 12, 2019February 25, 2022 by Targeting Phage Therapy

© Pete Wardell/USCDCP/Pixnio For years, antibiotic-resistant infections have been the bane of modern health care. Now, researchers have found a new way to attack some types of these nearly unstoppable microbes, Wired reports. In a study published this week in the Proceedings of the National Academy of Sciences, researchers identified a special alarm protein in…

Microbiota Quality and Mitochondrial Activity Link with Occurrence of Muscle Cramps in Hemodialysis Patients

Posted on April 25, 2019February 25, 2022 by Targeting Phage Therapy

Pilote study on Microbiota Quality and Mitochondrial Activity by Pierre-Yves Durand, Carole Nicco, Dedier Serteyn, David Attaf, Marvin Edeas BACKGROUND/AIMS: Hemodialysis-associated muscle cramp (HAMC) is a common complication under citrate dialysate (CD) occurring in 30% of cases. Our objectives were to assess the gut microbiota quality, mitochondrial activity, and to investigate their possible relationship with…

Prof. Marvin Edeas highlights: Microbiota and Phage Therapy – “Future Challenges in Medicine”

Posted on April 25, 2019April 29, 2019 by Targeting Phage Therapy

Dr. Armelle Paule, Prof.Dominico Frezza and Prof. Marvin Edeas published an article on Phage Therapy and Microbiota. An imbalance of bacterial quantity and quality of gut microbiota has been linked to several pathologies. New strategies of microbiota manipulation have been developed such as fecal microbiota transplantation (FMT); the use of pre/probiotics; an appropriate diet;…