Do phages or phage-based products select for less virulent bacterial population? University of Wroclaw, Poland

Prof. dr hab. Zuzanna Drulis-Kawa from the Department of Pathogen Biology and Immunology Institute of Genetics and Microbiology at University of Wroclaw, Poland, summarizes her talk in following :  “Most phages target bacterial surface molecules, especially those of carbohydrate nature, which are the dominant phage receptors. Surface glycans and glycoconjugates (polysaccharides PS) such as capsules and lipopolysaccharides (LPS) serve as molecular patterns for recognition by the innate immune system, and also provide shields to antibiotic entry and host defence mechanisms (e.g. complement system and phagocytosis). Loss or alteration of these molecules by gene mutation, which leads to phage resistance, could result in less virulent bacteria. This presentation shows a multidisciplinary approach to characterize bacterial population treated with phages and phage-based products and evaluate its consequences in terms of bacterial pathogenicity, interactions with the innate immune system, antibiotic resistance, and biofilm formation. “

If you are interested to know more about Phage and phage-based products, don’t hesitate to participate to Targeting Antibiotic Resistance Congress which will be held in Florence on October 2-3, 2017. More information on