Combined Therapies for Severely Infected Wounds: Multifunctional Bio-hybrids Composed of Gelatine Microspheres Carrying Bacteriophages and/or bFGF and their Aggregates with Mesenchymal Stem Cells

Dr. Farzaneh Moghtader, Istinye University, Turkey, will join the Phage Therapy Congress to present a talk entitled “Combined Therapies for Severely Infected Wounds: Multifunctional Bio-hybrids Composed of Gelatine Microspheres Carrying Bacteriophages and/or bFGF and their Aggregates with Mesenchymal Stem Cells”.

Recently Dr. Moghtader and her team have attempted to prepare bioactive hybrid materials for the treatment of mainly chronic wound infections like “Diabetic Foot Infection” – “DFI”) and “Diabetic Foot Osteomyelitis – “DFO”) using a combinational therapy. As bioactive materials bacteriophages as antibacterial agents and basic fibroblast growth factor (bFGF) and mesenchymal stem cells (MSCs) for regeneration of both soft and hard tissue were included within the formulations. Gelatin microspheres were prepared as the carrier matrices. Bacteriophages and bFGF were loaded within these crosslinked gelatin microspheres. Different release rates/modes were reached/observed. MSCs were isolated from the adipose tissue from mice, cultured and 3D aggregates were formed with or without gelatine microspheres. Viabilities and metabolic activities of the MSCs in 2D and 3D forms were followed 7-14 days in proper culture conditions and compared. Animal model studies are under investigation.

Targeting Phage & Antibiotic Resistance 2023
June 1-2, 2023 – Paris, France