Category: Latest News

Enhancing Precision in Phage Therapy: Insights from Phage Annotation and Nomenclature

Enhancing Precision in Phage Therapy: Insights from Phage Annotation and Nomenclature

Posted on by Targeting Phage Therapy
A paper  by Robert A Edwards and Bhavya Papudeshi from Flinders University, focused on refining the understanding and application of bacteriophages. Bacteriophages are viruses that infect bacteria, exerting a significant influence on microbial communities and ecosystems. They have garnered considerable attention for their potential role in combating antibiotic resistance. Phage therapy predominantly relies on lytic…
Posted on February 21, 2024
Read More
Exploring Phage Therapy: From Biological Mechanisms to Future Directions

Exploring Phage Therapy: From Biological Mechanisms to Future Directions

Posted on by Targeting Phage Therapy
Potential phage therapy applications from the One Health perspective In response to escalating antimicrobial resistance rates, the field of bacteriophage (phage) therapy, led by Robert T. Schooley and his team at the Center for Innovative Phage Applications and Therapeutics, Division of Infectious Disease and Global Public Health, University of California, San Diego, La Jolla, CA,…
Posted on February 15, 2024
Read More
Phage Therapy Targets Gut Microbiota for Liver Disease Treatment

Phage Therapy Targets Gut Microbiota for Liver Disease Treatment

Posted on by Targeting Phage Therapy
In a significant development, phage therapy is emerging as a solution against antimicrobial-resistant bacteria, marking a shift from conventional antibiotic treatments. Recognizing the intricate connection between bacterial microbiota and gastrointestinal/liver diseases, researchers are aiming to leverage phages’ precise bactericidal action for targeted editing of the gut microbiota. Fujiki et al. provided an overview of the…
Posted on February 9, 2024
Read More
Virus Attacks Dormant Bacteria, Offering New Hope in Antibiotic Resistance Fight

Virus Attacks Dormant Bacteria, Offering New Hope in Antibiotic Resistance Fight

Posted on by Targeting Phage Therapy
After six years of research, teams from the University of Basel and ETH Zurich have discovered a potentially crucial weapon against antibiotic-resistant bacteria: a virus named Paride that preys on and kills dormant bacteria. This bacterium, Pseudomonas aeruginosa, which can cause severe respiratory diseases and potentially fatal pneumonia, often enters a dormant state as a…
Posted on February 1, 2024
Read More
Bacteriophage Partnerships: Enhancing Stem Cell Transplant Success

Bacteriophage Partnerships: Enhancing Stem Cell Transplant Success

Posted on by Targeting Phage Therapy
Intestinal tissue during a graft-versus-host reaction: Donor cells (red) attack the body of the patient. Credit: Sebastian Jarosch, Dirk Busch / TUM After stem cell transplantation, the donated immune cells sometimes attack the patients’ bodies. This is known as graft versus host disease or GvHD. Researchers at the Technical University of Munich (TUM) and the Universitätsklinikum…
Posted on January 11, 2024
Read More
Rapid Bench to Bedside Therapeutic Bacteriophage Production

Rapid Bench to Bedside Therapeutic Bacteriophage Production

Posted on by Targeting Phage Therapy
An excellent paper by Luong et al. from San Diego State University has recently been published by Springer on Bacteriophage Therapy: From Lab to Clinical Practice. The comprehensive content of the paper includes: 1. Historical Context: Bacteriophages have been used in human therapeutics for over a century, with significant advancements in production techniques. 2. Modern…
Posted on January 11, 2024
Read More
How Bacteria Spot Viral Invasion and Ramp Up Immune Defenses?

How Bacteria Spot Viral Invasion and Ramp Up Immune Defenses?

Posted on by Targeting Phage Therapy
A viral RNA produced during Φ80α-vir infection activates Ssc-CdnE03 in vitro Researchers at The Rockefeller University’s Laboratory of Bacteriology have uncovered a novel mechanism through which bacteria defend against viral infections, known as the cyclic oligonucleotide-based antiphage signaling system (CBASS). This intricate immune response protects prokaryotes by triggering the production of cyclic oligonucleotides, activating proteins…
Posted on January 2, 2024
Read More
Phables: Advancing Phage Research for a Healthier Future

Phables: Advancing Phage Research for a Healthier Future

Posted on by Targeting Phage Therapy
Processing workflow. Credits: Flinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University In a significant leap forward for phage research, Flinders University’s College of Science and Engineering introduces “Phables”, a bioinformatics software program designed to address the challenges in identifying and characterizing phage genomes within fragmented viral metagenome assemblies. This innovative tool,…
Posted on December 28, 2023
Read More
New Structural Antibiotic Classes Discovered through Explainable Deep Learning

New Structural Antibiotic Classes Discovered through Explainable Deep Learning

Posted on by Targeting Phage Therapy
In the relentless pursuit of novel solutions to combat the escalating antibiotic resistance crisis, a groundbreaking paper, published in the Nature Journal, reveals a pioneering approach to the discovery of new structural classes of antibiotics. The paper challenges the current status quo in antibiotic discovery by leveraging the power of deep learning. Acknowledging the urgency…
Posted on December 26, 2023
Read More
Promising Path for Periprosthetic Hip Infection Recovery: The Power of Phage-Antibiotic Combination Therapy

Promising Path for Periprosthetic Hip Infection Recovery: The Power of Phage-Antibiotic Combination Therapy

Posted on by Targeting Phage Therapy
A new Russian study, published in the journal “Viruses”, study delves into the efficacy of combined phage/antibiotic therapy for treating periprosthetic joint infection (PJI) in adult patients with deep PJI of the hip joint. The research, which included 45 adult patients undergoing one-stage revision surgery, presents compelling evidence that could reshape the landscape of PJI…
Posted on December 5, 2023
Read More