Virus Attacks Dormant Bacteria, Offering New Hope in Antibiotic Resistance Fight

Virus Attacks Dormant Bacteria, Offering New Hope in Antibiotic Resistance Fight

After six years of research, teams from the University of Basel and ETH Zurich have discovered a potentially crucial weapon against antibiotic-resistant bacteria: a virus named Paride that preys on and kills dormant bacteria. This bacterium, Pseudomonas aeruginosa, which can cause severe respiratory diseases and potentially fatal pneumonia, often enters a dormant state as a…
Posted on February 1, 2024
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Bacteriophage Partnerships: Enhancing Stem Cell Transplant Success

Bacteriophage Partnerships: Enhancing Stem Cell Transplant Success

Intestinal tissue during a graft-versus-host reaction: Donor cells (red) attack the body of the patient. Credit: Sebastian Jarosch, Dirk Busch / TUM After stem cell transplantation, the donated immune cells sometimes attack the patients’ bodies. This is known as graft versus host disease or GvHD. Researchers at the Technical University of Munich (TUM) and the Universitätsklinikum…
Posted on January 11, 2024
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Rapid Bench to Bedside Therapeutic Bacteriophage Production

Rapid Bench to Bedside Therapeutic Bacteriophage Production

An excellent paper by Luong et al. from San Diego State University has recently been published by Springer on Bacteriophage Therapy: From Lab to Clinical Practice. The comprehensive content of the paper includes: 1. Historical Context: Bacteriophages have been used in human therapeutics for over a century, with significant advancements in production techniques. 2. Modern…
Posted on January 11, 2024
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How Bacteria Spot Viral Invasion and Ramp Up Immune Defenses?

How Bacteria Spot Viral Invasion and Ramp Up Immune Defenses?

A viral RNA produced during Φ80α-vir infection activates Ssc-CdnE03 in vitro Researchers at The Rockefeller University’s Laboratory of Bacteriology have uncovered a novel mechanism through which bacteria defend against viral infections, known as the cyclic oligonucleotide-based antiphage signaling system (CBASS). This intricate immune response protects prokaryotes by triggering the production of cyclic oligonucleotides, activating proteins…
Posted on January 2, 2024
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Phables: Advancing Phage Research for a Healthier Future

Phables: Advancing Phage Research for a Healthier Future

Processing workflow. Credits: Flinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University In a significant leap forward for phage research, Flinders University’s College of Science and Engineering introduces “Phables”, a bioinformatics software program designed to address the challenges in identifying and characterizing phage genomes within fragmented viral metagenome assemblies. This innovative tool,…
Posted on December 28, 2023
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New Structural Antibiotic Classes Discovered through Explainable Deep Learning

New Structural Antibiotic Classes Discovered through Explainable Deep Learning

In the relentless pursuit of novel solutions to combat the escalating antibiotic resistance crisis, a groundbreaking paper, published in the Nature Journal, reveals a pioneering approach to the discovery of new structural classes of antibiotics. The paper challenges the current status quo in antibiotic discovery by leveraging the power of deep learning. Acknowledging the urgency…
Posted on December 26, 2023
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Promising Path for Periprosthetic Hip Infection Recovery: The Power of Phage-Antibiotic Combination Therapy

Promising Path for Periprosthetic Hip Infection Recovery: The Power of Phage-Antibiotic Combination Therapy

A new Russian study, published in the journal “Viruses”, study delves into the efficacy of combined phage/antibiotic therapy for treating periprosthetic joint infection (PJI) in adult patients with deep PJI of the hip joint. The research, which included 45 adult patients undergoing one-stage revision surgery, presents compelling evidence that could reshape the landscape of PJI…
Posted on December 5, 2023
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Sterile Faecal Filtrate Transplantation Shows Promise in Managing Metabolic Syndrome, According to Double-Blind Clinical Trial

Sterile Faecal Filtrate Transplantation Shows Promise in Managing Metabolic Syndrome, According to Double-Blind Clinical Trial

Overview of the faecal samples used for the bulk metagenomic sequencing (for bacteriome and phageome) and the metagenomic sequencing of the viral-like particles (VLP) A double-blind, randomised, placebo-controlled clinical trial was conducted by a team in The Netherlands in order to assess the efficacy and safety of sterile faecal filtrate transplantation in individuals with metabolic…
Posted on November 28, 2023
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Therapeutically useful mycobacteriophages BPs and Muddy require trehalose polyphleates

Therapeutically useful mycobacteriophages BPs and Muddy require trehalose polyphleates

Proposed roles of Pks, PapA3, FadD23, MmpL10 and PE in the synthesis and transport of TPPs and DAT Mycobacteriophages show promise as therapeutic agents for non-tuberculous mycobacterium infections. However, little is known about phage recognition of Mycobacterium cell surfaces or mechanisms of phage resistance. A new study, led by Graham F. Hatfull from the University of Pittsburgh…
Posted on September 1, 2023
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Treating bladder infections with viruses

Treating bladder infections with viruses

The pathogens that cause urinary tract infections are becoming increasingly resistant to antibiotics. ETH Zurich researchers have now developed a rapid test and a new therapeutic approach using bacteria-​infecting viruses known as phages. In brief ETH Zurich researchers have developed a new rapid test that uses bacteriophages – viruses that infect bacteria – to quickly…
Posted on July 26, 2023
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