Category: Latest News

Engineering Therapeutic Phages: Towards Enhanced Antibacterial Efficacy

Engineering Therapeutic Phages: Towards Enhanced Antibacterial Efficacy

Posted on by Targeting Phage Therapy
Despite phage therapy demonstrating success in various individual cases of antimicrobial resistance, a comprehensive and unequivocal demonstration of the therapeutic potential of phages remains to be shown. The co-evolution of phages and their bacterial hosts resulted in several inherent limitations for the use of natural phages as therapeutics such as restricted host range, moderate antibacterial…
Posted on July 20, 2022
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Gut Bacteriophage Dynamics During Fecal Microbial Transplantation in Metabolic Syndrome Subjects

Gut Bacteriophage Dynamics During Fecal Microbial Transplantation in Metabolic Syndrome Subjects

Posted on by Targeting Phage Therapy
Metabolic Syndrome (MetS) is a growing public health concern worldwide. A healthy gut microbiota is associated with a reduction in MetS. Treatment of MetS with fecal microbiota transplantation (FMT) can be effective, however, its success rate is intermediate and difficult to predict. Because bacteriophages significantly affect the microbiota membership and function, the aim of this…
Posted on July 7, 2022
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Engineering T4 Bacteriophage for In-Vivo Display via Type V CRISPR-Cas Genome Editing

Engineering T4 Bacteriophage for In-Vivo Display via Type V CRISPR-Cas Genome Editing

Posted on by Targeting Phage Therapy
Bacteriophage T4 has enormous potential for biomedical applications due to its large size, capsid architecture, and high payload capability for protein and DNA delivery. However, it is not very easy to genetically engineer its genome heavily modified by cytosine hydroxymethylation and glucosylation. The glucosyl hydroxymethyl cytosine (ghmC) genome of phage is completely resistant to most…
Posted on July 7, 2022
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Luminescence Modulating Phages for Detecting Disease Associated Biomarkers

Luminescence Modulating Phages for Detecting Disease Associated Biomarkers

Posted on by Targeting Phage Therapy
Assessment of risk for a given disease and the diagnosis of diseases is often based on assays detecting biomarkers. Antibody-based biomarker-assays for diseases such as prostate cancer are often ambiguous and biomarker proteins are frequently also elevated for reasons that are unspecific. Kulpakko et al. have opted to use luminescence modulating phages for the analysis…
Posted on July 6, 2022
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Programmed M13 Bacteriophage Inspired Nose

Programmed M13 Bacteriophage Inspired Nose

Posted on by Targeting Phage Therapy
Based on the programable surface chemistry of M13 bacteriophage and inspired by the neural mechanism of the mammalian olfactory system, Lee et al., proposed an electronic nose. The neural pattern separation (NPS) was devised to apply the pattern separation that operates in the memory and learning process of the brain to the electronic nose. This…
Posted on February 24, 2022
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Phage Therapy Against SARS-Cov-2

Posted on by Targeting Phage Therapy
Non-tailed phages with multifaceted capsid morphology (Cystoviridae, Leviviridae, Corticoviridae, Tectiviridae) and pleomorphic phages (Plasmaviridae). Knowing that one of the life threatening aspects of COVID-19 is secondary infections and reduced efficacy of antibiotics against them, Shahin et. al, brilliantly discussed the potential applications of bacteriophages in the fight against the present pandemic and the post-COVID era.…
Posted on February 24, 2022
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Phage infection mediates inhibition of bystander bacteria

Posted on by Targeting Phage Therapy
Phage infection mediates inhibition of bystander bacteria Bacteriophages (phages) are being considered as alternative therapeutics for the treatment of multidrug resistant bacterial infections. Considering phages have narrow host-ranges, it is generally accepted that therapeutic phages will have a marginal impact on non-target bacteria. We have discovered that lytic phage infection induces transcription of type VIIb…
Posted on June 18, 2020
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Scientists hope to fight antibiotic-resistant bacteria by targeting their ‘alarm proteins’

Posted on by Targeting Phage Therapy
© Pete Wardell/USCDCP/Pixnio For years, antibiotic-resistant infections have been the bane of modern health care. Now, researchers have found a new way to attack some types of these nearly unstoppable microbes, Wired reports. In a study published this week in the Proceedings of the National Academy of Sciences, researchers identified a special alarm protein in…
Posted on December 12, 2019
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Microbiota Quality and Mitochondrial Activity Link with Occurrence of Muscle Cramps in Hemodialysis Patients

Posted on by Targeting Phage Therapy
Pilote study on Microbiota Quality and Mitochondrial Activity by Pierre-Yves Durand, Carole Nicco, Dedier Serteyn, David Attaf, Marvin Edeas BACKGROUND/AIMS: Hemodialysis-associated muscle cramp (HAMC) is a common complication under citrate dialysate (CD) occurring in 30% of cases. Our objectives were to assess the gut microbiota quality, mitochondrial activity, and to investigate their possible relationship with…
Posted on April 25, 2019
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